Introduction/Timeline of Genome Project

  • HGP Human Genome Project 1990-2003

  • aim to map the nucleotides contained in a human haploid reference genome (more than three billion).

    • The "genome" of any given individual is unique; mapping the "human genome" involved sequencing a small number of individuals and then assembling these together to get a complete sequence for each chromosome.
    • Therefore, the finished human genome is a mosaic, not representing any one individual.

  • the idea was picked up in 1984 by the US government when the planning started, the project formally launched in 1990 and was declared complete in 2003.

  • Funding came from the US government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside government by the Celera Corporation, or Celera Genomics, which was formally launched in 1998. Most of the government-sponsored sequencing was performed in twenty universities and research centers in the United States, the United Kingdom, Japan, France, Germany, Spain, Taiwan and China.

  • The Human Protein Atlas 2003-2017

  • TCGA: The Cancer Genome Atlas

    • TCGA - The Cancer Genome Atlas Project (2005-2017)

      • GDC Data Portal (Genomic Data Commons)

        • From The Cancer Genome Atlas (TCGA) consortium, a large-scale collaboration initiated and supported by the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI).

        • Identifying the changes in each cancer’s complete set of DNA – its genome – and understanding how such changes interact to drive the disease will lay the foundation for improving cancer prevention, early detection and treatment.

    • The Pan-Cancer Atlas (2018@CellPress)

      • "presents the Pan-Cancer Atlas, investigating different aspects of cancer biology by analyzing the data generated during the 10+ years of the TCGA project. "

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