The Pan-Cancer Atlas (2018@CellPress)

"The Cancer Genome Atlas (TCGA) team now presents the Pan-Cancer Atlas, investigating different aspects of cancer biology by analyzing the data generated during the 10+ years of the TCGA project. "

• Cell-of-Origin Patterns

• Oncogenic Processes

• Signaling Pathways

• Cell-of-Origin Patterns

• Flagship Paper

  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

• Companion Papers

  • Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
  • A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
  • Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas
  • Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous
  • The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

• Oncogenic Processes

• Flagship Paper

  • Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

• Companion Papers

  • Pathogenic Germline Variants in 10,389 Adult Cancers
  • Comprehensive Characterization of Cancer Driver Genes and Mutations
  • Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
  • The Immune Landscape of Cancer
  • Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy
  • A Pan-Cancer Analysis of Enhancer Expression in Nearly 9,000 Patient Samples
  • lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer
  • Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
  • Systematic Analysis of Splice-Site-Creating Mutations in Cancer
  • Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines
  • An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

• Signaling Pathways

• Flagship Paper

  • Oncogenic Signaling Pathways in The Cancer Genome Atlas

• Companion Papers

  • Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
  • Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas
  • Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
  • Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers
  • Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types
  • Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

Reference:

• Welcome to the Pan-Cancer Atlas
• Cell. Volume 173, Issue 2 April 05, 2018